Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia
نویسندگان
چکیده
منابع مشابه
The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancers.
Mutations or changes in protooncogenes and tumor suppressor genes are casually linked to human cancer pathogenesis. The RIZ gene is isolated based on the capacity its gene products to bind to the retinoblastoma tumor suppressor protein. Consistent with a potential role in the Rb pathway, RIZ may play an important role in human cancer pathogenesis. RIZ maps to human chromosome band 1p36, a regio...
متن کاملThe retinoblastoma-interacting zinc-finger protein RIZ is a downstream effector of estrogen action.
Co-immunoprecipitation experiments in cell extract from cultured cells or target tissues indicated that estrogen receptor was complexed with the retinoblastoma binding protein RIZ in a ligand-dependent manner. Mapping of interaction sites indicated that in both proteins the same regions and motifs responsible for the interaction of transcriptional co-activator and nuclear receptors were involve...
متن کاملThe retinoblastoma interacting zinc finger gene RIZ produces a PR domain-lacking product through an internal promoter.
The PR domain is a newly recognized protein motif that characterizes a subfamily of Krüppel-like zinc finger genes. Members of the PR domain family have been shown to play important roles in cell differentiation and malignant transformation. The RIZ gene is the founding member of this family; it was isolated because its gene products can bind to the retinoblastoma tumor suppressor protein. Here...
متن کاملPRDI-BF1-RIZ domain of retinoblastoma protein-interacting zinc finger gene 1 induces apoptosis and exerts anticancer activity in esophageal squamous cell carcinoma cells
The present study examined the role of the PRDI-BF1-RIZ (PR) domain of tumor suppressor retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) as an anticancer domain and its ability to induce apoptosis in esophageal squamous cell carcinoma (ESCC) cells. The TE13 ESCC cell line was transfected with pcDNA3.1(+) eukaryotic expression vectors bearing the open reading frames of either the hum...
متن کاملThe role of the retinoblastoma protein-interacting zinc finger gene 1 tumor suppressor gene in human esophageal squamous cell carcinoma cells
The tumor suppressor protein retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) is downregulated in several types of cancer, including esophageal squamous cell carcinoma (ESCC). The present study used two in vitro methods to re-express RIZ1 in the human ESCC TE13 cell line in order to induce apoptosis. RIZ1 was re-expressed in the TE13 cells by reintroducing the gene through transfect...
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ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2002
ISSN: 0007-1048
DOI: 10.1046/j.1365-2141.2002.03972.x